Today, Billboard debuted a new video featuring Eddie Vedder and one of the most prolific comedic film producers of this century, Judd Apatow, onstage together at Bonnaroo 2016, which Pearl Jam headlined. The clip is part of a promo push for Apatow’s new two-part HBO documentary, The Zen Diaries of Garry Shandling. The two-part project takes a deep dive into the life of his late mentor and comedy legend Garry Shandling with help from various famous friends and family members.During Judd’s scheduled “Judd Apatow & Friends” set at the festival’s Comedy Theater, Apatow explained, “I’m gonna bring out a friend and we’re gonna sing a song together in honor of my friend, Garry Shandling,” before Vedder strolled onstage to a chorus of cheers.As Eddie Vedder got set up with his music stand and acoustic guitar, Apatow explained, “Garry Shandling was my mentor. He gave me my first job. I wrote for the Grammys for Garry. And then I wrote for The Larry Sanders Show for Garry. … When he passed away we found these big stacks of diaries and journals, some of them very personal and some of them just filled with jokes. And when I was asked to do Bonnaroo, I said [to Eddie Vedder] ‘would you want to do this show?’ And Eddie said yes. And then the other day I said ‘what do you want to do?’ And he said ‘I was thinking about taking all of Garry Shandling’s writings and turning them into a song.’”Continues Apatow, “So then Eddie sent me a video of the song, and it was amazing. It’s a combination of his journals and jokes. And today I said ok let’s listen to the song, and he no you’re singing it with me…which is kind of not what anybody wants, not me or you [laughs]. But there is something nice about sharing our love for Garry…so I’m gonna sing this with Mr. Vedder.”The two go on to perform the song together, with Vedder handling the “very personal” writings, and Apatow peppering in the aforementioned stacks of jokes (like “My friends tell me I have an intimacy problem, but they don’t really know me” or “I shave one leg so it feels like I’m sleeping with a woman”). The result is a thoroughly enjoyable performance that’s at once hilarious and sincerely heartfelt by a couple masters in those respective specialties. You can watch the video below, courtesy of Billboard:Judd Apatow and Eddie Vedder In Concert – “Dear Mind” – From The Journals of Garry Shandling – Bonnaroo Comedy Theater – 6/11/16<span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>[Video: Billboard]The Zen Diaries of Garry Shandling is on HBO now.[H/T Billboard]
Researchers at Harvard-affiliated Brigham and Women’s Hospital (BWH) studying mesenchymal stem cells (MSCs) — a cell type useful in treating immune-related diseases — have uncovered a way to enhance and prolong the cells’ therapeutic effects in a preclinical model of Type 1 diabetes.The research team, led by Harvard Medical School (HMS) Professor Robert Sackstein of BWH’s Departments of Dermatology and of Medicine and HMS Associate Professor Reza Abdi of BWH’s Department of Medicine and Transplantation Research Center, reports its results this week in the journal Stem Cells.In Type 1 diabetes, the body’s immune cells obliterate pancreatic islets, where insulin is produced. MSCs are a type of adult stem cell with potent immune-suppressing and anti-inflammatory effects. In preclinical trials using diabetic-prone mice (non-obese diabetic mice), researchers had previously found that intravenous administration of MSCs could dampen pancreatic injury by reducing the levels of sugar in the mice’s bloodstreams without insulin administration, but these effects were modest and temporary.Sackstein and his team hypothesized that if more MSCs could be forced to populate inside the pancreatic islets, more islets could be spared from immune destruction, yielding a more complete reversal of diabetes.MSCs normally lack a key cell surface adhesion molecule called HCELL, which mediates the homing of cells in the bloodstream to sites of tissue inflammation. The injection of MSCs directly into pancreatic islets is not feasible because the pancreas is fragile and releases highly toxic enzymes when manipulated. To get intravenously administered MSCs to the sites of the immune attack, the research team engineered the HCELL homing molecule to steer them toward the inflamed pancreatic islets.The team found that administering HCELL-bearing MSCs into diabetic mice caused the MSCs to lodge in the islets. The result was durable normalization of blood sugar levels, eliminating the need for insulin administration — a sustained reversal of diabetesSackstein, co-corresponding author of the study, concluded that while further studies of the effects of MSCs are warranted, the preclinical study represents an important step in the potential use of mesenchymal stem cells in the treatment of Type 1 diabetes and other immune-related diseases.