Today, Phil Lesh has announced his 5th-annual birthday bash at his east coast home-away-from-home, The Capitol Theatre in Port Chester, NY. The three-night celebration is set to take place on March 14th, 15th, and 16h, 2019.Phil’s band lineups for the birthday shows, billed as Phil Lesh & Friends, have yet to be announced. However, an announcement from The Cap notes that Phil will be playing with “a fresh lineup of old friends and first-time collaborators.”Related: Celebrate Phil Lesh’s 78th Birthday With These Standout Performances From The Capitol TheatrePhil has played plenty of memorable shows at The Cap over the years—first as a member of the Grateful Dead and later with various Phil & Friends lineups since the venue was reopened in 2012. He was even presented with a key to the city of Port Chester in 2017. We can’t wait to get back to The Capitol Theatre with Phil in March and continue the tradition!For ticketing information, head here.
“Brain organoids can reproducibly make a large number of cell types that normally populate the endogenous brain. Although these neurons can extend axons and wire within circuits, at the moment, their connectivity is not organized like that of the actual brain,” Arlotta said. “By guiding axons of specific neurons to pre-defined targets, we would have an opportunity to engineer new connectivity, exactly as present in the intact organism. This is important for many reasons, not the least the possibility of understanding how diseases affect specific neurons and their networks to inform therapeutic progress.”This study was supported by the National Institute of Neurological Disorders and Stroke, the National Institute of General Medical Sciences, the National Institutes of Health, the Harvard Center for Biological Imaging, and the Harvard Stem Cell Institute. Harvard University researchers have developed an engineering technique to precisely control the direction that neurons grow their axons, cable-like structures that allow nerve cells to connect with each other. In a zebrafish model, researchers used the approach to correct defective neural connections and restore the neuron’s ability to cause muscle contractions.The findings, published in the journal Developmental Cell, represent a key step toward repairing nervous system damage in patients. They may also enable scientists to create more accurate models of the brain in a lab dish, by instructing the formation of precise neuronal connections resembling those of the actual brain.“The process of establishing connections between neurons mostly occurs during embryonic development, especially in mammals like us. After that point, if these connections are severed in situations such as spinal cord injury, the neurons typically do not regrow their connections, losing functionality. It would be a great achievement to be able to overcome these difficulties,” said Paola Arlotta, the Golub Family Professor of Stem Cell and Regenerative Biology. “This study is a proof of principle that shows the potential of a noninvasive strategy to direct neuron growth.”Forming connectionsA neuron’s axon is a projection that emanates from the cell body and connects to other cells, often located a great distance away. In the developing embryo, a complex set of signals guide a specialized structure at the tip of the axon, called the growth cone, to its precise target to wire the nervous system.,“Nature has come up with this beautiful symphony of molecular signaling that allows a tissue as incredibly complex as the brain to wire appropriately. We’re learning more and more about how this happens, but we don’t yet have the ability to direct all these intricate processes,” said James Harris, a graduate student in the Arlotta lab and lead author of the study. “Instead, we created an extremely precise tool that allows us to override the molecular signals within the body and guide axonal growth, according to our own designs.”By controlling axonal growth directly, this strategy avoids disrupting critical biological signaling molecules or introducing chemicals that might alter the delicate developmental environment, which could potentially cause unintended consequences on neighboring cells. To make sure the tool was highly specific, the researchers took an engineering approach to the problem.A noninvasive engineering approachTo control axon growth, the researchers introduced a fusion protein into specific neurons that combined the functionality of two different proteins. The first protein is normally expressed in developing axons, and controls the machinery responsible for axonal outgrowth. The second protein is originally found in plants and helps them to sense light.“Much in the way that plants grow toward the sun, we engineered the axons so they grow toward our targeted illumination,” Harris said.When the researchers shone a specific type of light near the neurons, the axons grew toward the noninvasive stimulus.,The researchers tested the approach in a zebrafish model, in collaboration with the Leonard Zon lab. They were able to not only make the neurons grow in a specific chosen direction, but also make the neurons grow across repulsive developmental barriers that normally restrict axons to a very narrow body location.“There are specific molecules that are expressed in these developmental barriers that help guide axons correctly during normal development. Interestingly, many of these molecules are also present in damaged tissue and act as barriers to axonal regeneration in mammals,” Harris said. “In this particular context of a developing zebrafish embryo, our approach had the power to overcome these inhibitory signaling molecules.”The researchers also studied a zebrafish model with genetic mutations that prevented axons from growing correctly. Their illumination approach successfully rescued this defect by guiding axons to their targets. The guided axons were able to cause muscle contractions in the zebrafish, demonstrating that the repaired connections were functional.Applying the technologyAlthough applying this technology to repairing injured connections in patients will require substantial additional work, this study is a promising step in this important direction. More immediately, the new technique can help scientists create more accurate models of the brain.“We are really interested in using this technology to wire more specific connections within human brain organoids,” Arlotta said.Made from human stem cells, organoids replicate important features of the developing nervous system in a lab dish. In a first, researchers use base editing to correct recessive genetic deafness and restore partial hearing Related New technology helps dissect how it ignores or acts on information Getting the brain’s attention A promise to a friend Up close and personal with neuronal networks
The Vermont and the New Hampshire Valley American Red Cross announced today the closing of the last of their thirteen emergency shelters that were opened around the state in response to Tropical Storm Irene. Longer term housing arrangements have been made for the last few residents at the Red Cross shelter at the Hartford High School in White River Junction and it officially closed as of noon. The widespread flooding and destruction from Irene forced many residents from their homes, and many took refuge in the thirteen Red Cross shelters that were opened after Irene hit Vermont on August 28, 2011. These Red Cross shelters were staffed with trained volunteers to meet the needs of the people staying there, including a safe place to stay, hot meals, emotional support and other assistance in response to the disaster. Now that water levels have receded and roads are being reopened, residents are able to return to their homes or to other longer-term housing arrangements. Red Cross emergency response vehicles have criss-crossed the state delivering food and clean-up supplies to residents after the storm, and Red Cross outreach teams have canvassed affected neighborhoods doing damage assessment and contacting residents to ascertain their emergency disaster relief needs. As the nature of the disaster response changes from immediate storm relief to longer term recovery efforts, the role of the Red Cross is also changing. The Red Cross will continue to provide disaster relief to those affected by Irene, and will also work with our disaster relief partner agencies in the longer term recovery for the state. ‘The American Red Cross is dedicated to providing disaster relief whenever storms such as Tropical Storm Irene impact our communities,’ said Timothy Stetson, Chief Response officer of the Vermont and the New Hampshire Valley American Red Cross. ‘Opening and staffing these shelters is just one of the many ways that the Red Cross helps our friends and neighbors every day.’ Stetson added that the Tropical Storm Irene response has been a huge disaster affecting thousands across multiple states, and the Red Cross response will cost millions of dollars. He asks if anyone would like to assist the Red Cross in helping others to consider making a donation. About the American Red Cross:The American Red Cross shelters, feeds and provides emotional support to victims of disasters; supplies nearly half of the nation’s blood; teaches lifesaving skills; provides international humanitarian aid; and supports military members and their families. The Red Cross is a charitable organization ‘ not a government agency ‘ and depends on volunteers and the generosity of the American public to perform its mission. For more information, please visit www.redcross.org(link is external) or join our blog at http://blog.redcross.org(link is external). please click, text or call to donate to American Red Cross Disaster Relief. Visit www.redcross.org(link is external) or text the word REDCROSS to 90999 to make a $10 donation. Contributions may also be sent to the American Red Cross Those who want to help can make a donation to support American Red Cross Disaster Relief. This gift enables the Red Cross to prepare for and provide shelter, food, emotional support and other assistance in response to disasters. Contributions may also be sent to local American Red Cross chapters or to the American Red Cross, P.O. Box 37243, Washington, DC 20013. 9.13.2011
On Tuesday, Trump reiterated his claims that Tlaib “hates Israel and all Jewish people,” and called her an “anti-Semite.”The president has repeatedly criticized “Squad Members” Rep. Tlaib and Rep. Ilhan Omar (D-Minn.) for their anti-Israel rhetoric.Last week, the Democrat lawmakers were denied entry to Israel because of their support of the boycott, divestment and sanctions (BDS) movement against the country.Trump was accused of pressuring Israel into the decision after suggesting Israel would look “weak” if it allowed the Congresswomen to enter.Tlaib, who is Palestinian American and an outspoken Trump critic, later requested and was granted a waiver to visit her grandmother in the West Bank.However, she reversed course a day later and announced she would not go.Reps. Tlaib and Omar held a joint press conference on Monday denouncing Israel’s decision.Tlaib teared up as she spoke about growing up in Israel and recounting her family’s experiences.“As a young girl visiting Palestine to visit my family I watched as my mother had to go through dehumanizing checkpoints even though she was a United States citizen and proud American,” Tlaib said, becoming emotional.Omar also suggested that lawmakers reconsider the annual U.S. aid allocated to Israel after they were prohibited from entering.Trump’s tweets on Tuesday came after coverage of the press conference played out on Fox News throughout the morning.It is the latest in his ongoing feud with Democrat lawmakers known as ‘The Squad.’Related content:President Trump v. The Squad – ‘If you hate our country, you can leave’ President Trump slammed Rep. Rashida Tlaib via Twitter Tuesday after a press conference where she emotionally criticized Israel over its decision to ban her from entering the country last week.Sorry, I don’t buy Rep. Tlaib’s tears. I have watched her violence, craziness and, most importantly, WORDS, for far too long. Now tears? She hates Israel and all Jewish people. She is an anti-Semite. She and her 3 friends are the new face of the Democrat Party. Live with it!— Donald J. Trump (@realDonaldTrump) August 20, 2019
The 2020-21 Premier League season is just around the corner, with the battle set to begin in earnest on Saturday, 12 September for the Premier League and La Liga and on Saturday, 19 September for Serie A.Arsenal and Liverpool will be raising the curtain on the highly anticipated season, with African superstars, Mohamed Salah and Pierre-Emerick Aubameyang going head to head when they meet in the FA Community Shield on Saturday, 29 August.MultiChoice Nigeria said in a statement yesterday that DStv subscribers will have a front-row seat to the football action on SuperSport 3 and SuperSport 10 when the game broadcasts live and in HD at 4:30pm, whilst GOtv Max and Jolli customers will have access to the game on SuperSport Select 2 at no extra cost! “In line with our mission to enrich the lives of our customers we felt it important to kick off this new football season with a wider broadcast of the anticipated clash and make it an inclusive experience for all our valued customers”, said John Ugbe, Chief Executive Officer, MultiChoice Nigeria.Arsenal will be looking to make a big statement in the clash, with their FA Cup triumph at the end of the last season, signaling their intent to return to glory in what will be manager Mikel Arteta’s first full campaign in charge.They also defeated Liverpool 2-1 when the teams last met – in a Premier League clash at the Emirates Stadium in mid-July – thanks to goals from Alexandre Lacazete and Reiss Nelson, though it was a match in which the Gunners clung on for the three points.Liverpool, meanwhile, are still basking in the glow of their first league title in 30 years, though manager Jurgen Klopp will want his side to quickly rediscover the hunger that drove them to glory through 2019-20.In addition to the big three leagues, SuperSport will also bring viewers an unprecedented coverage of the Euro 2020 Championship, UEFA Euro 2020 Qualifiers, European qualifiers for the 2022 FIFA World Cup in Qatar, the UEFA Champions League, and the UEFA Nations League.The breadth and depth of the coverage will include build-ups with respected analysts as well as language options for commentary including Pidgin. In addition, there will be a comprehensive coverage of football leagues, with hundreds of games from Premier League, La Liga (with exclusive English commentary) and Serie A, on the new dedicated thematic channels.Meanwhile, customers can enjoy more variety of football action with the ongoing Major League Soccer on ESPN, available on DStv packages and GOtv Max package.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram
A Jenny Grace goal and good play from Emer Mcdonnell had edged Burgess ahead in the Munster camogie championship but Milford responded with Aishling Thompson Anna Geary to the fore. At the end of a pulsating encounter the teams were tied 1-10 to 0-13 at half time.In extra time Milford edged ahead and it finished with Milford progressing on a final score of Burgess 1-13 Milford 0-18