Steering stem cell trafficking into pancreas reverses Type 1 diabetes

first_imgResearchers at Harvard-affiliated Brigham and Women’s Hospital (BWH) studying mesenchymal stem cells (MSCs) — a cell type useful in treating immune-related diseases — have uncovered a way to enhance and prolong the cells’ therapeutic effects in a preclinical model of Type 1 diabetes.The research team, led by Harvard Medical School (HMS) Professor Robert Sackstein of BWH’s Departments of Dermatology and of Medicine and HMS Associate Professor Reza Abdi of BWH’s Department of Medicine and Transplantation Research Center, reports its results this week in the journal Stem Cells.In Type 1 diabetes, the body’s immune cells obliterate pancreatic islets, where insulin is produced. MSCs are a type of adult stem cell with potent immune-suppressing and anti-inflammatory effects. In preclinical trials using diabetic-prone mice (non-obese diabetic mice), researchers had previously found that intravenous administration of MSCs could dampen pancreatic injury by reducing the levels of sugar in the mice’s bloodstreams without insulin administration, but these effects were modest and temporary.Sackstein and his team hypothesized that if more MSCs could be forced to populate inside the pancreatic islets, more islets could be spared from immune destruction, yielding a more complete reversal of diabetes.MSCs normally lack a key cell surface adhesion molecule called HCELL, which mediates the homing of cells in the bloodstream to sites of tissue inflammation. The injection of MSCs directly into pancreatic islets is not feasible because the pancreas is fragile and releases highly toxic enzymes when manipulated. To get intravenously administered MSCs to the sites of the immune attack, the research team engineered the HCELL homing molecule to steer them toward the inflamed pancreatic islets.The team found that administering HCELL-bearing MSCs into diabetic mice caused the MSCs to lodge in the islets. The result was durable normalization of blood sugar levels, eliminating the need for insulin administration — a sustained reversal of diabetesSackstein, co-corresponding author of the study, concluded that while further studies of the effects of MSCs are warranted, the preclinical study represents an important step in the potential use of mesenchymal stem cells in the treatment of Type 1 diabetes and other immune-related diseases.last_img read more

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One change to Tipp side for clash with Limerick

first_imgDonnagh Leahy comes in for the suspended Robbie Kiely after he received a straight red card last weekend against Armagh. With Daragh Dwyer taking Leahy’s place among the replacements. Evan Comerford has recovered from the ankle injury he sustained in the Round 1 game. With Alan Campbell, captain Paddy Codd and Andrew Morrisey all making up the full back line. The half backs are comprised of Seamus Kennedy, Peter Acheson and Donnagh Leahy. While Colin O’Riordain and Stephen O’Brien make up the midfield partnerships. The half forwards will be George Hannigan, Barry Grogan and Brian Fox, with Conor Sweeney, Michael Quinlivan and Ian Fahey making up the full forward line. Tipperary senior football selector Tommy Twomey says his side face a tough home game in Sunday’s Round 2 National League match-up.Click the link for the Tipp selector’s comments:  https://soundcloud.com/tippfmradio/tommy-twomey-speaks-to-tipp-fm-sport-ahead-of-sundays-round-2-match-up-against-limerickAfter defeat to Armagh last weekend, the Tipp side need to ensure victory in their four home ties with the first of those this weekend when they take on Limerick in Templetuohy. Tipp’s Munster rivals have momentum after their first round win over Sligo and Tommy Twomey says every game is now a battle for two points.The pitch at Semple Stadium was last night deemed unplayable with the Division 3 clash now moved to Templetouhy and throw-in will be at 2 o’clock. Tipp FM’s coverage of Sunday’s match is brought to you in association with O Connell’s Centra Templemore.last_img read more

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How taxpayers are cheating themselves

first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisWBKB spoke with certified public accountant Bernie Lamp, Straley Lamp and Kraezlein, on what taxpayers should do prior to filing for this year’s income tax returns.He said the first step is gathering all the necessary statements. For example, w-2 and 10-99 forms. In the same breath, Lamp said taxpayers are losing money in the bank by cutting themselves short.“One of the mistakes perhaps is not considering all the deductions they might be entitled to,” Lamp said. He also said there’s a lot of opportunity for business owners in particular.  “They can use the actual deductions of using a business vehicle versus [using] the IRS…standard mileage rate.”He said this could be more beneficial for taxpayers. Another example is contributing to individual retirement accounts. These accounts are deductible according to the CPA.Lamp said taxpayers are allowed to take a donation for the reasonable value of items they donate sent to thrift stores such as the ones in town.AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThis Tags: income tax, irs, losing money, savingsContinue ReadingPrevious Lakewood home fire classified as ‘accident’Next Field trips known to boost in-school successlast_img read more

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Reaction to Seagull’s thumping as Poch’s future hangs by thread

first_imgBRIGHTON welcome Tottenham to the Amex Stadium as they search for their first home win this season.But Spurs come into this match off the back of a harrowing 7-2 defeat to Bayern Munich on their own turf, while they haven’t won away in the Premier League since January.And the clash on the south coast started off in horrible circumstances for the North Londoners, as they conceded in the opening minutes after Hugo Lloris could only palm a cross onto Neal Maupay, who headed into an empty net from a yard out.But Tottenham’s bad luck continued, as the Frenchman was unable to carry on after falling awkwardly on his elbow and could be set for a lengthy spell out.Tottenham winless away from home in nine league matchesBrighton with just one victory in 16 Premier League gamesWatch on BT Sport 1 from middayLive stream via app for BT Sport customersEE phone subscribers can sign up for three-month FREE trial to use BT Sport appBrighton XI: Ryan, Webster, Dunk, Burn, Montoya, Stephens, Mooy, Alzate, Gross, Maupay, ConnollySubs: Button, Bong, Balogun, Bissouma, Jahanbakhsh, Murray, MarchTottenham XI: Lloris, Sissoko, Alderweireld, Vertonghen, Davies, Dier, Ndombele, Eriksen, Lamela, Son, KaneSubs: Gazzaniga, Foyth, Sanchez, Skipp, Winks, Alli, Mouralast_img read more

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