Rip Van Microbe has awakened after 120,000 years, said Live Science without batting an eye. That’s strange; human observation only goes back 1/12 of that time max. The bacterium came out of its suspended animation and grew as if nothing had happened. “Such vigor is partially due to the microbe’s small size, the scientists speculate,” the article said. “Tiny microbes like this one can also hide more easily from predators and take up residence among ice crystals and in the thin liquid film on those surfaces.”No scientist would have “speculated” such a thing before. This could just as easily have falsified the belief that the Greenland location was as old as claimed, but no— evolutionary dating must survive all empirical challenges. Let’s see if we have a law of nature that has been discovered. If longevity is inversely proportional to size, flies should outlive humans. Wrong. If longevity is a function of ability to hide more easily from predators, gophers should outlive humans. Wrong. It seems the only law of nature we have discovered is that Darwinians are incorrigible storytellers.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0
Inside the Casa de Chocolate. Photo by geocacher TramossosGeocache Name:Hansel and Gretel e a Casa de Chocolate (GC468WD)Difficulty/Terrain Rating:5/3Why this is the Geocache of the Week:When I first saw this geocache, the thing that struck me was the incredible description! I didn’t understand any of it (I don’t speak Portuguese), but I could definitely see the time and effort that went into creating the story and images. From there, a quick look at the logs and the photos showed that this geocache was more than just a pretty description—the container itself is an elaborate puzzle box. Geocache owners that put this much effort into a geocache deserve to be recognized!What geocachers are saying:[translated as best I could from Portuguese]“I really enjoyed it, Falkon Eye congratulations, this was the best cache I’ve ever done.” – eduarda“Magnificent cache !! Certainly deserves all the praise it has received, and from us, a BIG FAVORITE POINT. Congratulations to the owner throughout their dedication to create this geocache.” – SACTeam“Very, very, very good! Shoe-in for (at least) the top 3. Congratulations to the owner on the GREAT accomplishment and thanks for giving us the pleasure of enjoying this MAGNIFICENT cache.” – avilescosPhotos:A lucky geocacher with the logbook. Photo by geocacher Lusitana PaixãoYou’ve got the box, now how do you get it open? Photo by geocacher NarsaThe beginning of this geocache’s page. SharePrint RelatedConcrete floats! — Betonschiff Redentin (GC15D8C) — Geocache of the WeekDecember 4, 2013In “Community”Started from the bottom, now we’re here. — Roof of the World (GC9A9E) — Geocache of the WeekMay 22, 2013In “Community”Karst Mountain Topography — Yangshuo – GE9 — Geocache of the WeekNovember 5, 2015In “Geocache of the Week” What’s the most elaborate geocache you’ve ever found? Tell us in the comments.Continue to explore some of the most engaging geocaches around the globe. Check out all the Geocaches of the Week on the Geocaching blog. If you would like to nominate a Geocache of the Week, just fill out this form. Thanks!Share with your Friends:More Português
Photo Attribution: KT KingBefore the season started I made some predictions about how the Cowboys would fare this year, and specifically how prolific Brandon Weeden would perform in his senior campaign.I looked like a fool coming out of the gate after he looked average against Louisiana but everything came together last weekend in College Station for, surely, the most spectacular half of quarterbacking OSU has ever had.Let’s take a look at where we are with some of those predictions I made as well as a few other Weeden superlatives through four games.I said Brandon Weeden…Would throw more TDs than he did last year (34) – On pace for 32.5, easily within reach.Would break the completion percentage record he set last year of .669 – Currently at an absurd 74.3%Would be in New York City on December 10 – I’m going to be the conductor of this train until it happens or we careen off the tracks.Would become OSU’s all-time leading passer – Needs to average 243 the rest of the way. I’m pretty confident that’s going to happen.Would set the career TDs thrown record this year – Needs 18 more to tie Zac. That’s definitely hanging in the balance, but I say he gets it. Hell, he might throw for 7 or 8 against KU and Baylor.Weeden currently has more passing yards than 71 other teams have total yards.He leads the nation in attempts per game (48) and is on pace to throw 621 times this year which would break the school record he set last year by 110 throws. BJ Symons says, “so?”He leads the nation in completions per game (36) and is on pace to complete 462 passes which would break his school record by 120 completions.Only eleven other QBs have completed more passes in an entire year than Weeden has through four games.On Sunday Pat Jones said this about Weeden:This guy might be Barry Sanders playing quarterback.Pat is confused and sounds like he’s just trying to spew hyperbole because to compare someone, statistically or otherwise, to Barry Sanders is not a good basis for any argument.The point remains though, that the aged gunslinger from Edmond is conjuring up historical comparisons the likes of which we’ve never seen come through Stillwater. I hope you’re enjoying the ride.This post is part of a season-long series on the Heisman hopes of Brandon Weeden and Justin Blackmon. Click here to read more.If you’re looking for the comments section, it has moved to our forum, The Chamber. You can go there to comment and holler about these articles, specifically in these threads. You can register for a free account right here and will need one to comment.If you’re wondering why we decided to do this, we wrote about that here. Thank you and cheers!
Prior to Sunday’s SEC Tournament championship game, Arkansas’ players did some trash talking to their opponent, Kentucky. They reportedly got in the Wildcats’ faces in a Bridgestone Arena tunnel and Razorbacks’ forward Bobby Portis said being able to play UK was like getting a wish granted. The fervor Arkansas’ players have for Kentucky is a feeling that is apparently replicated by the Wildcats’ players. Following his team’s victory against the Razorbacks, Kentucky junior center Willie Cauley-Stein said “we don’t like that team,” referencing Arkansas. Wow. Willie keeping it REAL. “We don’t like that team.” Said winning title was one thing, but they just wanted to beat “that team.”— Ashley Scoby (@AshleyScoby) March 15, 2015Willie Cauley-Stein after the game re: Arkansas, “Straight up, we don’t like that team.”— Brett Dawson (@BDawsonRivals) March 15, 2015Full WCS quote on not liking “that team” pic.twitter.com/EoGtkE2VTJ— Ashley Scoby (@AshleyScoby) March 15, 2015It’s not often that you see college basketball players openly discussing their dislike for another team, but we love it. Kentucky and Arkansas will learn their place in the NCAA Tournament at 6 p.m. E.T. on CBS.
Minister of Labour and Social Security, Hon. Shahine Robinson (right), speaks with Country Coordinator of Winrock International, Cheryl Davis Ivey, at the launch of the ‘Labour Department and You’ Road Show, which was held at the Rudolph Elder Park in Morant Bay, St. Thomas, on Tuesday (February 26). The initiative is aimed at bringing the services of the department to citizens across the island, as well as to heighten awareness about its programmes and policies. Minister of Labour and Social Security, Hon. Shahine Robinson, addresses the launch of the ‘Labour Department and You’ Road Show, which was held at the Rudolph Elder Park in Morant Bay, St. Thomas, on Tuesday (February 26). The initiative is aimed at bringing the services of the department to citizens across the island, as well as to heighten awareness about its programmes and policies.
Advertisement Facebook LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Login/Register With: Advertisement Twitter After weathering lackluster critical scores and OK fan response with last year’s Batman V. Superman: Dawn Of Justice and Suicide Squad, all is well and correct in the Warner Bros/DC universe as Wonder Woman is both a hit with critics (94% Certified Fresh Rotten Tomatoes) and audiences, earning an A CinemaScore on top of her current $97.1 million opening.Out of all the titles in the WB/DC canon, Wonder Woman owns one of five rare A grades along with Batman, Batman Begins, The Dark Knight and The Dark Knight Rises. Today will determine whether Wonder Woman propels past $100M, and a few believe it’s not out of the question.Four weeks ago, Wonder Woman arrived on tracking at $65M and just grew from there — to $75M three weeks out, and $90M a few days before its opening. Not only is that evidence of Warner Bros’ marketing machine working effectively, but it’s also an example of what happens when Rotten Tomatoes works in a tentpole’s favor, especially as there’s a groundswell of great reviews days before a film opens.
Tamara Pimemtel APTN NewsTwo correctional officers and two managers were fired recently at the maximum security prison in Edmonton.There were allegations of harassment, intimidation, bullying and there may be possible criminal offences.Keith Chief Moon worked in correctional facilities across Alberta for over 30 years.He’s an elder and brings in cultural practices.He is concerned, but not surprised, about the firstname.lastname@example.org
Source:https://www.rockefeller.edu/news/25535-new-hope-treating-childhood-brain-cancer/ Reviewed by James Ives, M.Psych. (Editor)Apr 5 2019There could be new treatments on the horizon for diffuse intrinsic pontine glioma, or DIPG, a devastating form of brain cancer that afflicts young children and is currently incurable. Recent experiments in animal models of the disease have identified an experimental drug that effectively destroys DIPG cells. And a team of Rockefeller scientists just figured out how this promising compound works.The research, described in Proceedings of the National Academy of Sciences, shows that the drug acts on cellular cholesterol pathways, and suggests that these pathways may be fruitful targets for treating a variety of brain cancers.Targeting tumorsDIPG tumors are located in the pons, a highly sensitive structure that connects the brain to the spinal cord. Surgical removal of tumors is effectively impossible since it poses the risk of fatal brain damage. And although radiation can be used to temporarily reduce symptoms, the cancer inevitably grows, with an average survival rate of less than one year. Which is to say: there is a pressing need for new ways to treat children with the disease.An auspicious development came in 2014 from a collaboration between the labs of C. David Allis, the Joy and Jack Fishman Professor, and Viviane Tabar, Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center (MSKCC). The team showed that a compound known as MI-2 stops tumor growth in a mouse model of DIPG. The drug was already on scientists’ radar for the treatment of leukemia, and was known to work on leukemia cells by interacting with menin, a protein that regulates gene expression. So when Allis’ team began investigating the effect of MI-2 on DIPG cells, they initially suspected that it would work in a similar manner.”Our first hypothesis was that the drug switched off genes by interacting with menin,” says Richard Phillips, a neuro-oncologist at MSKCC and a visiting fellow in the Allis lab who spearheaded this effort. “But as we probed a little bit further, many of the things that we would expect to see didn’t pan out.”Related StoriesResearchers report how a popular antidepressant drug could rewire the brainHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancerFor example, when the researchers genetically removed menin from glioma cells, those cells remained sensitive to MI-2, indicating that the compound exerted its effects via a pathway distinct from that observed in leukemia. The scientists then discovered that DIPG cells exposed to MI-2 failed to maintain healthy levels of cholesterol, and quickly died; but the cells could be rescued with a dose of supplemental cholesterol–suggesting that, in the case of glioma, MI-2 works by depleting the nutrient. Eventually, the researchers discovered that MI-2 directly inhibits lanosterol synthase, an enzyme involved in cholesterol production.The researchers also found that, while MI-2 destroys glioma cells, the drug doesn’t damage normal brain cells. This finding is consistent with other research showing that some cancer cells are particularly vulnerable to cholesterol disturbances.Building better drugsThis study contributes to a growing body of research pointing to cholesterol interference as a promising new way to treat cancer. Moving forward, Phillips and his colleagues hope to develop compounds that are optimized for targeting brain cancer. As a starting point, they are studying a number of cholesterol-reducing compounds that are already on the market.”Some existing drugs, initially made for people with high cholesterol, were designed to target lanosterol synthase–but they were never really thought of as cancer drugs,” he says. “One of them is even more potent than MI-2, so we’re now working with a team of chemical biologists to see if we can modify the drug so that it reaches the brain.”More broadly, this research highlights the importance of knowing not just that a drug works, but how it works. In this case, the discovery that MI-2 acts on lanosterol synthase revealed that DIPG tumors are sensitive to cholesterol interference–a finding that opens avenues for the production of even more effective compounds.Says Phillips: “You can’t assume that what it says on the label is actually how a drug works.”
Reviewed by Alina Shrourou, B.Sc. (Editor)Apr 24 2019Unconscious bias has become a hot topic recently, with high profile incidents reported around the world. Researchers at Aalto University are exploring the causes of these biases in our neural wiring, and are developing techniques using MRI scanners that let us see the brain making assumptions in real time. The results show for the first time that the brain is not only unconsciously biased towards people based on appearance, but it also forms biases based on what we know about the person as well.Peoples’ brains are naturally biased towards other people who are the same as them – a behavioral trait scientists call ‘in-group favoritism’. The opposite trait is also true: people are often naturally biased against people who are not the same as them, called ‘out-group derogation’. Mamdooh Afdile – a filmmaker studying for a PhD in neuroscience at Aalto University – decided to use cinema to explore this.Afdile used the film Priest to create a 20-minute stimulus film version that explored biases in two social groupings: heterosexual and homosexual men. ‘If knowledge gained from our social environment can implicitly bias how we perceive each other, this should hold true to characters in movies as well,’ Afdile explained. To see if watching the movie biased the viewers subconsciously, Afdile flashed the face of the protagonist repeatedly for a brief duration of 40 milliseconds before and after showing the movie.Even though the viewer wouldn’t be able to notice being shown a person’s face – much less have time to recognize the person – their subconscious brain responded to the flashed face based on whether or not they had become biased. By using functional MRI, the researchers were able to detect how people’s biases could be changed.Related StoriesRepurposing a heart drug could increase survival rate of children with ependymomaDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustRush University Medical Center offers new FDA-approved treatment for brain aneurysmsIn the beginning of the movie, the viewer gets the impression that the priest is heterosexual and falling in love with a woman. At the 10 minute mark, the viewer finds out the priest is in fact in love with another man. The study groups watching the film consisted of 14 homosexual and 15 heterosexual men, and the team measured the bias felt by each group towards the priest character when they thought he was straight, and when they knew he was gay.The social groupings were chosen by the researchers because, unlike race or gender, we cannot perceive another person’s sexual orientation just by looking at their face – so any bias response by the participants in the experiment toward the face presented to them would be dependent on what they came to know about the person. The subconscious response to the face of the protagonist after seeing the movie, compared to before seeing it, was significantly different between the two groups, and this result was not symmetrical. The results from the heterosexual group showed a very mild negative bias response, and interestingly those from the homosexual group showed a very strong response in brain regions associated with in-group, such as empathy and favoritism.These results are interesting for our understanding of unconscious bias because they demonstrate that the brain responds in a biased way to traits it can’t detect using our basic senses.’This study shows the brain can be biased based on learned knowledge and not only by external factors,’ explains. Mamdooh Afdile. By combining movies with subliminal measurement we can now investigate the subconscious brain in ways that were extremely difficult before.’ Source:https://www.aalto.fi/news/brain-scans-on-movie-watchers-reveal-how-we-judge-people
© 2018 AFP Citation: Volkswagen sees ‘good start’ to 2018 despite slip in profits (2018, April 26) retrieved 18 July 2019 from https://phys.org/news/2018-04-volkswagen-good-profits.html German car giant Volkswagen on Thursday reported a small drop in profits but nonetheless said strong sales got the year off to “a good start”, as new CEO Herbert Diess pushes on with a post-dieselgate revamp of the behemoth. Volkswagen makes 15-bn-euro bet on electric cars in China Explore further Volkswagen CEO Herbert Diess has vowed to steer the company out of the Dieselgate cloud and continue its pivot towards the greener, cleaner cars of the future VW said it booked a net profit of 3.22 billion euros ($3.9 billion) between January and March, down nearly three percent on the same period a year earlier and slightly below analyst expectations.Underlying or operating profit slipped by 3.6 percent to 4.2 billion euros, the firm said, blaming the drop mainly on accounting changes and negative currency effects.Revenues hit 58.2 billion euros, up 3.6 percent year-on-year, as the VW group with its stable of 12 brands delivered a record 2.7 million vehicles in the first quarter.In a statement, the Wolfsburg-based company said the year was “off to a good start”.Demand for VW vehicles—which also includes luxury Audi and Porsche and the more affordable Skoda and Seat makes—was driven by the Asia-Pacific region, led by China’s strong appetite for SUVs.”Once again, the growth driver was the Chinese passenger car market,” VW said.The picture in western Europe was more mixed, with sales slowing in Italy and Britain, while dealerships in Germany were boosted by the robust economy and the popularity of a trade-in scheme for older diesel engines.The first-quarter results are the first to be announced since VW brand chief Diess unexpectedly replaced Matthias Mueller as chief executive earlier this month, as the group seeks to draw a line under the diesel emissions rigging scandal.Mueller was himself brought in to rescue VW after the company admitted in 2015 to installing cheating software in 11 million diesel vehicles worldwide to dupe pollution tests.While Mueller managed to bring VW’s share price and profits back up to pre-crisis levels, he himself landed in prosecutors’ sights and the company remains mired in a sea of legal woes at home and abroad.Diess has vowed to steer the car titan out of the dieselgate cloud and continue VW’s pivot towards the greener, cleaner cars of the future.Much of the focus will be on China, where VW this week pledged investments of 15 billion euros in electric and autonomous vehicles by 2022, in cooperation with local joint-venture partners.”The quarterly results confirm we are on the right path,” Diess said. “It is now a matter of pursuing this course in a strong and focused manner.”Looking ahead, the group confirmed that it expects to increase revenue by “as much as 5.0 percent” compared with the previous year.It will also target an operating profit margin before special items of between 6.5 and 7.5 percent, compared with 7.4 percent last year.The group said the main challenges this year were likely to come from economic headwinds, stronger competition and the continued fallout from the diesel scandal, including tough new EU emissions rules. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.