Nov 2, 2009 (CIDRAP News) – Interim clinical trial findings announced today affirm that children younger than 10 need two pandemic H1N1 vaccine doses, and initial findings in pregnant women reveal no safety concerns and a need for only one dose.Federal officials also detailed the role of an independent panel of experts to review vaccine safety data and released a report outlining the government’s vaccine safety monitoring system.At a media briefing today, Bruce Gellin, MD, director of the National Vaccine Program at the US Department of Health and Human Services (HHS), said federal officials realize that, despite problems with vaccine supply and demand, Americans still have concerns about its safety. He told reporters that an independent expert group charged with reviewing vaccine safety data met for the first time today to become familiar with the data sources they’ll be reviewing.In addition, a federal task force today released a 20-page report that outlines beefed-up systems that officials have put in place to monitor the safety of the vaccine. US health officials are mindful of the 1976 swine flu vaccination campaign, which reached more than 40 million people but was associated with an increase in cases of Guillian-Barre syndrome, a temporary paralytic condition.Though vaccine safety and purifications steps are much more advanced today, officials have added new systems to track the pandemic H1N1 vaccine and are taking extra steps to add transparency to the process, in hopes of reassuring the public.Anne Schuchat, MD, director of the CDC’s National Center for Immunization and Respiratory Diseases, told reporters that a cumulative total of 30 million doses of pandemic H1N1 vaccine have been produced for states to order, which represents an increase of 3.4 million since Friday.Vaccine data for childrenThe latest findings of vaccine efficacy in children come on the heels of a recommendation from World Health Organization (WHO) vaccine experts who on Oct 30 recommended that most people, even young children, receive just one dose of the vaccine.Though the group acknowledged they didn’t have much data to base their guidance on, they said countries that have placed children as a high-priority group to receive the vaccine should administer one dose so they can immunize as many children as possible.Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said the findings today, from National Institutes of Health (NIH) studies, are critical to public health officials who are charged with making policy decisions and to the public for making personal decisions for themselves and their loved ones.He said interim results on vaccine in healthy children ages 6 months to 17 years confirm early results reported on Sep 21. The new findings show that children younger than 10 who receive a second 15-microgram (mcg) dose of pandemic H1N1 vaccine have significant immune response improvement.The new data were obtained 8 to 10 days after the second vaccine dose, compared with the first findings, which were obtained 21 days after the first dose.In the youngest children (6 to 35 months), 100% had a robust immune response after the second dose compared with only 25% after the first dose. In those ages 3 through 9, 94% had a robust immune response after the second dose, compared with 55% after the first dose.Immune responses were comparable in those receiving two 15-mcg doses and in those who got two 30-mcg doses, suggesting that the smaller dose is enough to elicit a strong immune response, according to an NIH press release today.”Our guidelines seem to fit quite nicely with the science,” Fauci said at the news conference. “We would like to get children as fully protected as we can.”Efficacy in pregnant womenIn the initial results on the vaccine in pregnant women, immune response to the pandemic H1N1 shot was similar to that seen in healthy adults.Public health officials have placed pregnant women at the front of the line to receive the vaccine because they have been disproportionately hit by the virus. So far the CDC has received reports of at least 100 pandemic flu infections in pregnant women that required intensive care unit (ICU) treatment, as well as reports of 28 deaths.In a subgroup of 50 pregnant women participating in an NIH clinical trial, a preliminary analysis of blood drawn 21 days after vaccination showed the vaccine was likely protective in 23 of 25 women (92%) who received a single 15-mcg dose and that it was likely protective in 24 of 25 (96%) who received a single 30-mcg dose.The trial began on Sep 9, according to an NIH press release. Participants were between ages 18 and 39 and were in their second or third trimester when they began the study. The ongoing study will also assess the effects of a second dose. Investigators are using Sanofi’s pandemic H1N1 vaccine, which does not contain the preservative thimerosal or an immune-response-boosting adjuvant.Despite the heightened threat of the virus to pregnant women, public health officials worry about the uptake of the pandemic vaccine in this group, because only about 15% of pregnant women typically receive the seasonal vaccine. Safety monitoring of the drug conducted by researchers and an independent expert panel so far suggests that the vaccine is well tolerated, with no safety concerns so far.”For pregnant women, who are among the most vulnerable to serious health problems from 2009 H1N1 infection, these initial results are very reassuring,” Fauci said.Vaccine-safety groupGellin said the independent vaccine safety expert group that met today in its first face-to-face meeting will meet biweekly to review the latest data and will report its findings each month in a publicly accessible conference call with the HHS’s National Vaccine Advisory Committee.The vaccine safety group will be receiving regular briefings from the NIH and the Biomedical Advanced Research and Development Agency (BARDA) and can convene rapidly if needed.See also:Nov 2 NIH press release on vaccine response in childrenNov 2 NIH press release on vaccine response in pregnant womenFederal Immunization Task Force report on plans for monitoring pandemic H1N1 vaccine safetySep 21 CIDRAP News story “Trial predicts 2 H1N1 shots for young kids, 1 for older”
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Mariners sign Ichiro Suzuki ahead of expected Japan sendoff, report says Dipoto denied the accusations, calling them “untrue,” and took responsibility for the controversy that came after he fired her for cause just one year into her three-year contract. He had hired Martin in October 2017 as the team’s high performance director to help the team modernize its training and conditioning regimes, a position Dipoto created.”At the end of the day, my belief is that justice will prevail,” Dipoto said Thursday, per The Seattle Times. “There is an ongoing investigation that I’m not going to get into. I’ve been at this now for 30 years. I know a lot of people in this game. I’m not sexist, nor am I a racist. The accusations that have been made are untrue. I believe that will wash out as this unfolds. But I can only speak for myself. The responsibility for the development of the program and hiring Dr. Martin to come here was on me and I take full responsibility for it. I’m embarrassed at how this has unfolded.” Related News MLB is investigating Martin’s claims, including a post she made on social media in November implied Dipoto, McKay and manager Scott Servais had called Latino players “lazy, dumb and stupid.” Martin has since filed a wrongful termination lawsuit against the franchise, according to the Times. She claims in the suit she complained earlier this year to team owners John Stanton, Buck Ferguson and CEO Kevin Mather about alleged discrimination, to no avail. Mariners general manager Jerry Dipoto strongly denied accusations of racism and sexism made by former staffer Dr. Lorena Martin on Thursday for the first time since the allegations surfaced in November.Dipoto and director of player development Andy McKay, who also was named in the allegations, reiterated the team’s belief Martin fabricated claims against members of the front office. “It’s a difficult situation, obviously,” McKay said. “It’s one that requires thought and it requires reflection. But in terms of the people I work with on a daily basis the support has been unanimous and 100 percent positive. The accusations are serious, but they are completely false. I never said anything like that. I’ve never thought that. I’ve never felt it. It didn’t happen.“Fortunately, I think I have a track record with people I’ve worked with, not just here, but in Colorado and in Sacramento that this is not just very believable. I’m not planning on addressing it. I haven’t addressed it. This is the first time I’ve addressed it. And I’m grateful for the Mariners. They’ve supported me. Major League Baseball is doing an investigation that is very thorough and very complete. And at the end of it, I’ll feel very good about where my name will stand.”The Mariners issued a statement in November denying all of the accusations, calling them “outrageous, false claims.”
Andy Ruiz Jr. shocked the boxing world on June 1. He was a massive 11-1 underdog coming into his fight with British superstar Anthony Joshua, and most analysts believed that Joshua would make short work of the challenger. Ruiz proved to be more than anyone expected, though, rebounding from being knocked down in the third round to knock down Joshua four times on his way to winning the unified heavyweight title. MORE: Follow the latest odds and betting trends with Sports Insider His most impressive victory to date came the following year when he dropped Wladimir Klitschko to unify the heavyweight division. Joshua added the WBA and IBO heavyweight belts to his waist by beating Klitschko in a thriller at Wembley Stadium, and he acquired the WBO title in 2018 when he beat Parker by unanimous decision. He went on to defend his four titles successfully only once before his loss to Ruiz.What’s next?This is the deepest we have seen the heavyweight division in years, and the winner of this bout will likely be involved in the class’ biggest fight in 2020. If Ruiz can beat Joshua again, he will likely face the winner of the Deontay Wilder-Tyson Fury rematch in February, in what could be a full unification title fight. A Joshua victory could lead to a long-awaited bout with either Wilder or Fury, or he could decide to make it a trilogy and take on Ruiz for a third and final time next year. A win would make him the most marketable boxer in the division, giving him the opportunity to make any fight he wanted. It was the best fight of 2019 so far, and a rematch was essentially guaranteed. The two heavyweights will meet in what is being labeled as the “Clash On The Dunes” Saturday afternoon in Diriyah, Saudi Arabia. The action will start with the undercard fights getting underway at noon ET, while the main event is slated to begin at 3:45 p.m. ET.The WBA, IBF, WBO, and IBO titles will be on the line, and the bout will be exclusively shown on DAZN in the United States and Canada. Andy Ruiz Jr. vs. Anthony Joshua 2 oddsAlthough Ruiz won the first fight, he is still an underdog on Saturday afternoon, according to the latest boxing betting odds. Joshua is a -205 favorite in a bout that is not expected to go the distance. The odds on the fight lasting all 12 rounds are +250, and the over/under for the number of rounds we will see has been set at 7.5.Join DAZN to watch Ruiz vs. Joshua 2 & 100+ fight nights a yearCan Andy Ruiz Jr. pull off the upset again?Ruiz has been overlooked throughout his professional career. Even with a record of 28-0, he was unable to get marquee prize fights, and it appeared that he would never get his moment in the sun after a loss by majority decision to Joseph Parker for the WBO heavyweight title in December 2016. He took over a year off before entering the ring again, but he came back with a fury. Ruiz knocked out Devin Vargas in the first round in March 2018, and he proved he had the stamina to go the distance in a win by unanimous decision over Kevin Johnson four months later. An impressive win over Alexander Dimitrenko set up the first fight between Ruiz and Joshua, and Ruiz took full advantage of the opportunity.Ruiz comes into the rematch with a record of 33-1. He has knocked out his opponent in 22 of those fights, showcasing his raw power, but his quickness is his real calling card. Ruiz catches opponents off guard with how fast his hands and feet move, leading to some improbable knockouts.MORE: Ruiz vs. Joshua 2 odds, pick, prediction, betting trends & prop betsAnthony Joshua is out to reclaim his beltsJoshua was heralded as the best heavyweight fighter in the world prior to his loss to Ruiz. The 6-6 boxer is the prototype of a heavyweight champion, and he seemed set to rule the division for a decade prior to his stunning defeat.The former gold medalist is 22-1 in his professional career, and 21 of his victories have come by knockout. Joshua’s dominance as an amateur led to him being placed on the fast track to greatness, and he won his first major belt back in April 2016 when he defeated Charles Martin by knockout in the second round to claim the IBF strap.
Photo by Tristan Tamayo/INQUIRER.netJustine Baltazar buried the go-ahead basket as La Salle came back to beat National University, 80-76, for its first win in the UAAP Season 81 men’s basketball tournament Wednesday night at Mall of Asia Arena.Balztazar hit a jumper from the left baseline off an inbound pass to put the Green Archers ahead, 78-76, with 28 seconds left.ADVERTISEMENT Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Gov’t to employ 6,000 displaced by Taal “I think I’ve ran that play for like a 100 times in practice. Like what I told you guys before Justine will play a big role for us this season,” said La Salle coach Louie Gonzalez, whose squad rallied from 11 points down in the second period.“I told him to shoot when he gets the ball,” Gonzalez recalled of his crucial play that left Baltazar wide open.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSJapeth Aguilar wins 1st PBA Finals MVP award for GinebraSPORTSGolden State Warriors sign Lee to multiyear contract, bring back ChrissThe third-year big man notched a double-double with 17 points and 12 rebounds while Aljun Melecio led all scorers with 19 points for La Salle, which bounced back from a 68-61 loss to Far Eastern University on September 9.The Archers ended the game on a 6-0 spurt after Troy Rike gave the Bulldogs a 76-74 edge with 1:42 remaining. For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. Tim Cone, Ginebra set their sights on elusive All-Filipino crown Phivolcs: Slim probability of Taal Volcano caldera eruption MOST READ LATEST STORIES Gretchen Barretto’s daughter Dominique graduates magna cum laude from California college “Whatever the odds, the adversity they faced earlier in the game, I looked at them and saw their composure,” Gonzalez, who is in his first year at La Salle’s helm following the transfer of Aldin Ayo to University of Santo Tomas in December of last year.Rookie Dave Ildefonso led NU, which slipped to 1-1, for the second straight game with 16 points.Rike had 15 points and six rebounds but missed two free throws that would’ve put NU in the driver’s seat with 53 ticks remaining.The Bulldogs faltered when it mattered most with major lapses on both ends in the last two minutes.Up by two, 76-74, Enzo Joson fouled Melecio while taking a 3-pointer with Melecio making 2-of-3 free throws with 1:25 left.ADVERTISEMENT View comments Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Japeth Aguilar embraces role, gets rewarded with Finals MVP plum Nadine Lustre’s phone stolen in Brazil Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Asia League: Bad luck hits iECO as Howell ‘doubtful’ for PH team’s next game Don’t miss out on the latest news and information. Allen Durham still determined to help Meralco win 1st PBA title Sports Related Videospowered by AdSparcRead Next NU also couldn’t get the ball inbounds after Baltazar’s jumper and wasted a chunk of the time left before intentionally fouling to stop the clock.Andrei Caracut sealed the game with a pair of freebies with only 11 seconds to go.
Dear Editor,The principles and practice of collective bargaining are being ignored, undermined, or sabotaged by public authorities in the public service and the University of Guyana, contrary to established and agreed procedures between the trade unions and the organisations. In short, the procedures in sequential stages require direct negotiations, conciliation/mediation, and finally arbitration. Ignoring or violating these procedures is contrary to the spirit and intent of the labour laws, and International Labour Convention Treaties ratified by the Republic of Guyana and notified to the international community of the United Nations and the International Labour Organisation.Accordingly, reference is made to general principles to our national Constitution, and in particular, some relevant International Labour Convention Treaties, and labour laws on the fundamental principles and rights at work including:Convention No 87: Freedom of association and protection of the right to organise;Convention No 98: the right to organise and collective bargaining, and which obligates the State, public and private authorities to provide adequate protection of trade unions exercising their right to organise and collective bargaining to regulate the terms and conditions of employment;Convention No 151: Labour relations (Public Service) provides the same rights and protection accorded under Convention No 98 for the Private Sector employees, through negotiations, conciliation/mediation, and arbitration;the Labour Act – Chapter 98:01 on the settlement of industrial disputes; andthe Trade Union Recognition Act – No 33 of 1997 obligating the employer and the recognised trade union to confer and bargain in good faith in the collective bargaining process. This law is clear – failure or refusal on the part of either the employer or trade union constitute an offence and liable on summary convection to payment of fines.Any aggrieved trade union should challenge the management in the Private or Public Sector – in count, for failure or refusal to bargain in good faith, or indulging in subterfuge or bad faith in negotiations in collective bargain. The University of Guyana and the public service unions, or the Department of Labour should resort to the courts, as may be necessary, to ensure that there is full observance of the principles, legal, and treaty obligations to bargain in good faith.Wake up trade unions at the University of Guyana, and the public service and promote and protect the interests of your members through collective bargaining. Members of unions should take the leadership of unions to court for failure or refusal to bargain in good faith on their behalf in keeping with the agreed or established representation procedure in the collective bargaining process.Yours sincerely,Joshua Singh